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  • Title: Lithium-sensitive production of inositol phosphates during amphibian embryonic mesoderm induction.
    Author: Maslanski JA, Leshko L, Busa WB.
    Journal: Science; 1992 Apr 10; 256(5054):243-5. PubMed ID: 1314424.
    Abstract:
    Mesoderm induction and body axis determination in frog (Xenopus) embryos are thought to involve growth factor-mediated cell-cell signaling, but the signal transduction pathways are unknown. Li+, which inhibits the polyphosphoinositide (PI) cycle signal transduction pathway in many cells, also disrupts axis determination and mesoderm induction. Amounts of the PI cycle-derived second messenger, inositol 1,4,5-trisphosphate, increased during mesoderm induction in normal embryos; addition of Li+ inhibited the embryonic inositol monophosphatase and reversed this increase. Embryonic PI cycle activity thus shows characteristics that indicate it may function in mesoderm induction and axis determination.
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