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  • Title: [Study of the effect of tetracycline carboxamide derivatives on the cardiovascular and urinary systems].
    Author: Aleutskiĭ NN, Berger DIa.
    Journal: Antibiotiki; 1975 May; 20(5):467-70. PubMed ID: 131506.
    Abstract:
    The effect of tetracycline carboxamide derivatives, such as morphocycline, glycocycline and reverin on the cardio-vascular and urinary systems was studied on 24 rabbits using clinico-physiological and pathomorphological methods. The experiment was accounted for 7 days. When the drugs were administered in doses of 5 mg/kg, the changes in the indices of hemodynamics, respiration and bioelectric activity of the myocardium were rather of the same type. They were evident from decreased arterial pressure, slower rate of the pulse and respiration, lower voltage of peaks R and T, prolongation of intervals T--P and R--P, shifts in segment S--T from the isoelectric line. The changes took place by the 2nd and 5th minutes after the drug administration. Beginning from the 10th minute the hemodynamic indices returned to the initial values. By the level of the drugs effect on the above indices the antibiotics may be arranged in the following order: morphocycline, glycocycline and reverin. No effect of the antibiotics on the urinary system was noted.
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