These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: D-galactosamine-induced cell damage enhances specific binding of prostaglandin E1 to rat hepatocytes.
    Author: Matsumoto M, Kikuchi E, Okamoto Y, Morimura M, Kitano H, Fukui H, Nakano H, Tsujii T.
    Journal: Biochem Biophys Res Commun; 1992 Apr 30; 184(2):654-60. PubMed ID: 1315527.
    Abstract:
    Specific bindings of [3H]prostaglandin E1 ([3H]PGE1), 125I-glucagon and [3H]norepinephrine to D-galactosamine (GalN)-treated rat hepatocytes in primary culture were investigated. After a two hour-treatment with GalN (1 and 10mg/ml), hepatocytes showed an enhanced specific binding to [3H]PGE1, whereas 125I-glucagon binding was little affected and [3H]norepinephrine binding was strongly diminished. Scatchard plot analysis indicated an increase of binding sites of [3H]PGE1. This unusual manner of [3H]PGE1 binding is suggested to indicate a special property of PGE1 receptor and may be associated with the cytoprotective effect of prostaglandins.
    [Abstract] [Full Text] [Related] [New Search]