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  • Title: The need for clinical awareness of polymorphous low-grade adenocarcinoma: a review.
    Author: Norberg L, Dardick I.
    Journal: J Otolaryngol; 1992 Apr; 21(2):149-52. PubMed ID: 1316446.
    Abstract:
    Adenocarcinomas of the salivary glands are a heterogeneous group both in terms of histomorphology and clinical course. One recently described adenocarcinoma, polymorphous low-grade adenocarcinoma (solely of minor salivary gland occurrence), is appropriately named. This neoplasm has a wide spectrum of histology and can resemble tumors such as pleomorphic adenoma and adenoid cystic carcinoma; both aspects can lead to diagnostic problems for the pathologist. As well, despite an infiltrative growth pattern, which frequently results in perineural invasion, this tumor has a low local recurrence rate and a remarkable infrequency of local or distant metastasis. In order to provide appropriate therapy for polymorphous low-grade adenocarcinoma, oral and head and neck surgeons must be familiar with this neoplasm.
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