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  • Title: Fibrous dysplasia with locally aggressive malignant change.
    Author: Latham PD, Athanasou NA, Woods CG.
    Journal: Arch Orthop Trauma Surg; 1992; 111(3):183-6. PubMed ID: 1316773.
    Abstract:
    This is a case report of a tumour which showed all the histological features of fibrous dysplasia without any features of high-grade malignancy, yet had become locally aggressive, causing cortical erosion and extension into soft tissue. Fibrous dysplasia is a well-recognised entity that encompasses monostotic lesions, polyostotic involvement and Albright's syndrome [6, 8]. Lesions in bone usually spare the epiphysis before puberty, but often involve the epiphyseal area after maturity and can progress during adult life [3]. Unless cystic [6, 10] or malignant change [7, 10, 11] occurs, fibrous dysplasia usually remains contained within bone.
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