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  • Title: Inhibitory effect of rhynchophylline on platelet aggregation and thrombosis.
    Author: Chen CX, Jin RM, Li YK, Zhong J, Yue L, Chen SC, Zhou JY.
    Journal: Zhongguo Yao Li Xue Bao; 1992 Mar; 13(2):126-30. PubMed ID: 1317985.
    Abstract:
    Rhynchophylline (Rhy) inhibited rabbit platelet aggregation induced by arachidonic acid (AA), collagen, and ADP. The values of IC50 were 0.72, 0.74, and 0.67 mmol.L-1, respectively. Rhy reduced the thromboxane B2 (TXB2) generation in PRP induced by collagen but failed to reduce that induced by AA. Rhy suppressed malondialdehyde (MDA) formation in platelet suspension stimulated by thrombin, inhibited the platelet factor 4 (PF4) release. It did not alter intraplatelet cAMP concentration. Rhy 10-20 mg.kg-1 iv showed a significant inhibition of venous thrombosis and cerebral thrombosis in rats.
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