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  • Title: A previously uncharacterized gene, PML, is fused to the retinoic acid receptor alpha gene in acute promyelocytic leukaemia.
    Author: Goddard AD, Borrow J, Solomon E.
    Journal: Leukemia; 1992; 6 Suppl 3():117S-119S. PubMed ID: 1318462.
    Abstract:
    It has become apparent that a number of genes disrupted by chromosomal rearrangements during leukaemogenesis encode protein factors involved in transcriptional regulation (20-25) and PML may be another such gene. The replacement of the NH2-terminal transactivation domain in RAR alpha by the PML putative DNA binding and transactivation domains in the PML/RARA fusion produces a novel chimeric protein which may act to block normal myeloid differentiation through disregulation of the genes normally regulated by either or both of the normal proteins.
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