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  • Title: [3H-tert-butylbicyclo-ortho-benzoate--a new ligand for chloride ion channel of GABA-A receptor].
    Author: Golovko AI, Sofronov GA.
    Journal: Biull Eksp Biol Med; 1992 Feb; 113(2):155-6. PubMed ID: 1319233.
    Abstract:
    The study was made of the binding of 35S-t-butylbicyclophosphorothionate and 3H-t-butylbicycloorthobenzoate (TBOB) which label a GABAA receptor-regulated chloride ionophores to glass fiber filters GF/B and GF/C. The rate of 3H-TBOB binding was higher. GABA displayed a biphasic effect on 3H-TBOB binding to rat brain synaptic membrane; enhancement at low concentrations of the agent and inhibition at higher ones. The results suggest that GABA may modulate the 3H-TBOB binding.
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