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  • Title: [Activation of delta-opiate receptor simultaneously stimulates ACTH beta-endorphin and prolactin release].
    Author: Xu R.
    Journal: Zhongguo Yi Xue Ke Xue Yuan Xue Bao; 1992 Apr; 14(2):105-9. PubMed ID: 1319850.
    Abstract:
    To evaluate a possible physiological and pathological role of brain delta-opiate receptor and endogenous ligands in the control of ACTH, beta-endorphin (beta-EP) and prolactin (PRL) release, a specific agonist of the delta-opiate receptor--[D-Pen2, D-Pen5]-enkephalin (DPDPE) was microinjected into the third cerebral ventricle (1 microgram or 3 micrograms/3 microliters/rat) in conscious freely-moving male rats. Plasma ACTH, beta-EP and PRL concentrations were measured by radioimmunoassay (RIA). Our results clearly indicate that third ventricular injection of DPDPE significantly elevates plasma ACTH, beta-EP and PRL levels in comparison with control values, and that the stimulatory effects of DPDPE on the release of the three hormones are dose-related at 1 and 3 micrograms. The data suggest that activation of the delta-opiate receptor may be a mechanism behind the concomitant release of ACTH, beta-EP and PRL during stress and certain pathologic conditions.
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