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  • Title: The neuropathology of hereditary spastic paraparesis.
    Author: Bruyn RP.
    Journal: Clin Neurol Neurosurg; 1992; 94 Suppl():S16-8. PubMed ID: 1320499.
    Abstract:
    Hereditary spastic paraparesis or Strümpell's disease is a genetically determined neurodegenerative disorder in which the signs and symptoms are predominant in the legs. Inheritance is usually autosomal dominant and in a minority recessive. Neuropathological study reveals a degeneration of the corticospinal tract decreasing from lower lumbar to cervical level and of posterior columns increasing from lumbar to upper cervical level as well as degeneration of the spinocerebellar tracts in approximately 50%. The nature of this nucleo-distal central axonopathy and clinicopathological discrepancy for posterior columns, as well as the limits of the pathological process are poorly understood.
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