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  • Title: Activation of TIMP-2/progelatinase A complex by stromelysin.
    Author: Miyazaki K, Umenishi F, Funahashi K, Koshikawa N, Yasumitsu H, Umeda M.
    Journal: Biochem Biophys Res Commun; 1992 Jun 30; 185(3):852-9. PubMed ID: 1320876.
    Abstract:
    Progelatinase A was purified as a complex with TIMP-2 from the conditioned medium of a human glioblastoma cell line. The TIMP-2/progelatinase complex was resistant to the activation by p-aminophenylmercuric acetic acid (APMA), and showed less than 10% of the activity of the TIMP-2-free active enzyme. When the complex was incubated with stromelysin in the presence of APMA, the 64-kDa progelatinase was effectively converted to the 57-kDa mature enzyme, increasing its gelatinolytic activity about 8-fold. These results suggest that stromelysin is a natural activator of TIMP-2-bound progelatinase A.
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