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  • Title: The calcium second messenger system in bipolar disorders: data supporting new research directions.
    Author: Dubovsky SL, Murphy J, Christiano J, Lee C.
    Journal: J Neuropsychiatry Clin Neurosci; 1992; 4(1):3-14. PubMed ID: 1320969.
    Abstract:
    Studies of aberrations in second messenger function may help to elucidate some of the multiple complex neurobiological alterations in bipolar affective disorders. The phosphatidylinositol and calcium ion (Ca2+) second messengers are of particular interest because of evidence of hyperactivity of these signaling mechanisms in both mania and bipolar depression and of their normalization by lithium and other mood-stabilizing treatments. Because the intracellular Ca2+ signal has a biphasic action, a single aberration could explain diverse clinical manifestations of the same illness, and a single action on the messenger could explain the biphasic actions of many treatments for bipolar disorders.
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