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  • Title: Identification of multiple biological factors in rabbit serum that modulate dopamine-mediated aortic constriction.
    Author: Leone MG, Silvestrini B, Palmery M, Cheng CY.
    Journal: Biochem Int; 1992 May; 26(6):1079-90. PubMed ID: 1321620.
    Abstract:
    A bioassay was established using freshly prepared rabbit aortic strip to monitor the effects of various biological factors contained in rabbit serum that modulate vasoconstriction. Serotonin was shown to be a major vasoconstriction modulator in rabbit serum. A rapid procedure is described for its isolation from rabbit serum by sequential gel filtration chromatography and reversed-phase HPLC using C4, C18, and C2/C18 columns with an overall cumulative yield of about 20%. It was also noted that rabbit serum contains multiple biological factors that modulate dopamine-mediated aortic contraction other than serotonin. A potent vasoconstriction inhibitor was identified in rabbit serum which appears to be a novel regulator that mediates its effect via both alpha-adrenergic and serotonin receptors.
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