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  • Title: New chemotactic peptide analogs with high biological activity for human neutrophils.
    Author: Spisani S, Traniello S, Giuliani AL, Torrini I, Pagani Zecchini G, Paglialunga Paradisi M, Gavuzzo E, Mazza F, Pochetti G, Lucente G.
    Journal: Biochem Int; 1992 May; 26(6):1125-35. PubMed ID: 1321622.
    Abstract:
    As a part of a research programme aimed at studying structure activity relationships in the field of chemotactic peptides, modified analogs of the chemoattractant N-formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP) were examined for their capacity to activate several functions of human neutrophils. 4-Aminotetrahydrothiopyran-4carboxylic acid (Thp) and 2-aminoindane-2-carboxylic acid (Ain) were chosen as achiral, conformationally restricted amino acids suitable for mimicking the external Met and Phe residues of FMLP-OMe. The replacement of both produces a high locomotion activity, greater than the parent peptide; in contrast, the two Thp-containing analogs induce neither superoxide production nor lysozyme release. From these results we can hypothesize two different signal transduction systems: one which provides for movement, the other for superoxide generation and granule enzyme release.
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