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  • Title: Regulation of peripheral-type benzodiazepine receptors following repeated benzodiazepine administration.
    Author: Calvo DJ, Medina JH.
    Journal: Funct Neurol; 1992; 7(3):227-30. PubMed ID: 1323506.
    Abstract:
    The effects of chronic benzodiazepine (BZD) treatment on rat peripheral-type benzodiazepine receptors (PBR) were studied. Five days treatment with the PBR ligands RO 5-4864 or diazepam (DZ) up-regulates kidney PBR. In contrast clonazepam, a specific central-type BZD receptor ligand, did not alter 3H-RO 5-4864 binding. Fourteen days administration of DZ produced an up-regulation of kidney and heart PBR and a down-regulation of testicular PBR. The results suggest that chronic BZD exposure differentially regulates PBR in peripheral organs.
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