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  • Title: Role of amino acid residue 187 of poliovirus polypeptide 2C in determining the guanidine trait.
    Author: Baltera RF, Tershak DR.
    Journal: Intervirology; 1992; 33(3):165-72. PubMed ID: 1323552.
    Abstract:
    Although mutations in codons 164 and 179 of poliovirus polypeptide 2C can establish guanidine resistance, the majority of guanidine-resistant and guanidine-dependent viruses contain an M----L change at amino residue 187 along with other critical mutations. The change at residue 187 probably contributes to the guanidine phenotype along with a variety of other modifications in polypeptide 2C, possibly altering conformation of the polypeptide during the initiation step of viral RNA synthesis.
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