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  • Title: [Role of the hydrophobicity of monoquaternary ammonium compounds in the mechanism of their curariform action].
    Author: Drozhzhin AP, Ibadova DN.
    Journal: Farmakol Toksikol; 1975; 38(3):289-94. PubMed ID: 132360.
    Abstract:
    The lengthening of the alkyl radical at the quaternary nitrogen atom (from -C2H5 to -C20H41) in the series of alkyltrimethylammonium compounds was found to lead to a gradually growing hydrophobicity of the compound. A change in the mechanism responsible for the myoparalytic action of the compound is due to a mounting degree of hydrophobicity. With the methyl group in the molecule of tetramethylammonium replaced with polyalicyclic radicals (bornyl, adamantyl) the compound, acting after a non-depolarizing type, possess a greater degree of hyrophobicity than do substances of the depolarizing type.
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