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  • Title: Multimerization of ICP0, a herpes simplex virus immediate-early protein.
    Author: Chen J, Panagiotidis C, Silverstein S.
    Journal: J Virol; 1992 Sep; 66(9):5598-602. PubMed ID: 1323713.
    Abstract:
    ICP0, a herpes simplex virus immediate-early gene product, is a highly phosphorylated nuclear protein that is a potent activator of virus and host genes. Using biochemical and genetic assays employing plasmids encoding mutant forms of ICP0 and a recombinant adenovirus that expresses ICP0, we mutant forms of ICP0 and a recombinant adenovirus that expresses ICP0, we provide evidence that the protein multimerizes. Some mutant forms of ICP0 were transdominant and interfered with activation of a target reporter gene or with complementation of an ICP0-minus virus.
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