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  • Title: Comparison between first- and second-generation test for anti-hepatitis C virus antibodies in hemodialysis patients.
    Author: Da Porto A, Poli P, Calzavara P, Castelletto MR, Adami A, Cascone C, Amici GP, Teodori T, Okolicsanyi L.
    Journal: Nephron; 1992; 61(3):367-8. PubMed ID: 1323794.
    Abstract:
    The serum of 387 hemodialysis patients from 9 dialysis units was checked for anti-hepatitis C virus antibodies with a 1st-generation ELISA (Ortho) test: 61 patients were repeatedly positive. In order to avoid false-positive results, these sera were tested with a 1st-generation confirmatory RIBA test, 2nd-generation screening ELISA test and 2nd-generation confirmatory RIBA test. The 2nd-generation ELISA test confirmed data obtained with 1st-generation ELISA, however, the 1st-generation confirmatory RIBA test underestimated the number of anti-HCV-positive patients.
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