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  • Title: [Synthesis of a new neuromuscular blocking agent, pipecuronium bromide (Arduan)].
    Author: Tuba Z, Mahó S.
    Journal: Acta Pharm Hung; 1992 May; 62(3):73-81. PubMed ID: 1323916.
    Abstract:
    A series of bisquaternary ammonio steroids having androstane skeleton have been prepared some of which possessed high neuromuscular blocking activity. One of the series 3 alpha, 17 beta-diacetoxy-2 beta, 16 beta-bis (4,4-dimethyl-1-piperazinyl)-5 alpha-androstane dibromide (19, pipecuronium bromide, ARDUAN) has proved to be a clinically useful agent of long duration of action without side effects. The preparation of pipecuronium bromide and its metabolites and the impurities are also described. The structure of 19 and related compounds was elucidated by spectrometric methods IR, NMR and MS.
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