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  • Title: Effects of streptozotocin added in vitro on insulin biosynthesis and release in isolated rat islets.
    Author: Maldonato A, Trueheart P, Renold AE.
    Journal: Horm Metab Res; 1976; Suppl 6():71-3. PubMed ID: 132395.
    Abstract:
    The effect of different concentrations of streptozotocin was tested in vitro on isolated rat islets. The following parameters of islet-cell activity were measured: 1) incorporation of 3H-leucine into proinsulin and into total islet protein; 2) IRI release into the medium, and 3) islet proinsulin content. It appears from the preliminary results shown here that both insulin release and biosynthesis were decreased by streptozotocin in a way which was dose- and time-dependent.
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