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  • Title: Na+K+ATPase activity and ouabain binding sites in erythrocytes in hyperthyroidism before and after treatment.
    Author: De Riva C, Chen S, Virgili F, Frigato F.
    Journal: J Endocrinol Invest; 1992 May; 15(5):363-7. PubMed ID: 1324264.
    Abstract:
    Erythrocyte sodium pump is decreased in hyperthyroid patients. We described the effect of untreated hyperthyroidism on Na+K+ATPase activity, ouabain binding sites and intracellular sodium concentration. We found a reduction in Na+K+ATPase activity and in number of ouabain binding sites with a concomitant increase in intracellular sodium. B-blockade therapy failed to restore normal pump activity and sodium concentration, where only thionamide treatment was successful when it was able to decrease free T3.
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