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  • Title: Glycolipids of a human glioma cell line bearing receptors for platelet-derived growth factor (PDGF).
    Author: Yates AJ, Agudelo JD, Sung CC.
    Journal: Lipids; 1992 Apr; 27(4):308-10. PubMed ID: 1325593.
    Abstract:
    Glycolipids of U-1242 MG were characterized because results of previous studies showed that exogenous gangliosides, especially GM3, inhibit PDGF-stimulated growth of this human glioma cell line. GM3 and GM2 are the major gangliosides; both separate as doublets with thin-layer chromatography. The major neutral glycolipid is glucocerebroside with nonhydroxy fatty acids, but paragloboside, ceramide dihexoside, globoside, and asialoGM2 (GA2) are also present. The coexistence in U-1242 MG of these gangliosides and the PDGF receptor, whose mitogenic signal is modulated by GM3 in these cells, suggests a possible functional relationship among them with respect to growth regulation.
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