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  • Title: Rat surfactant protein D enhances the production of oxygen radicals by rat alveolar macrophages.
    Author: Van Iwaarden JF, Shimizu H, Van Golde PH, Voelker DR, Van Golde LM.
    Journal: Biochem J; 1992 Aug 15; 286 ( Pt 1)(Pt 1):5-8. PubMed ID: 1325783.
    Abstract:
    Rat surfactant protein D (SP-D) was shown to enhance the production of oxygen radicals by rat alveolar macrophages. This enhancement, which was determined by a lucigenin-dependent chemiluminescence assay, was maximal after 18 min at an SP-D concentration of 0.2 micrograms/ml. Surfactant lipids did not influence the stimulation of alveolar macrophages by SP-D, whereas the oxygen-radical production of these cells induced by surfactant protein A was inhibited by the lipids in a concentration-dependent manner.
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