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  • Title: PAF receptors and G-proteins in human blood eosinophils and neutrophils.
    Author: Agrawal DK, Ali N, Numao T.
    Journal: J Lipid Mediat; 1992; 5(2):101-4. PubMed ID: 1326343.
    Abstract:
    Identification of G-proteins and coupling of PAF receptors to G-proteins have been examined in the membranes of human blood eosinophils and neutrophils. Heterotrimeric G-proteins, Gi and GS, were present in both cell types, as demonstrated by immunoblotting and ADP-ribosylation with pertussis toxin. In addition, a group of low molecular mass (18-28 kDa) monomeric G-proteins was also identified. Pertussis toxin and GTP gamma S attenuated the specific binding of [3H]PAF, suggesting the occurrence of coupling between pertussis toxin-sensitive Gi protein and PAF receptors in eosinophils and neutrophils.
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