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  • Title: Increased erythrocyte Na+ pump and NaK-ATPase activity during lithium therapy.
    Author: Hokin-Neaverson M, Burckhardt WA, Jefferson JW.
    Journal: Res Commun Chem Pathol Pharmacol; 1976 May; 14(1):117-26. PubMed ID: 132687.
    Abstract:
    A significant mean increase of 18% in erythrocyte sodium pump activity (p less than 0.01, t test) was observed during lithium treatment, as compared with the activity before lithium treatment was started, in a group of 20 patients who were treated with lithium therapy for a variety of psychiatric conditions. The mean level of erythrocyte membrane ouabain-sensitive ATPase activity in a group of 35 subjects who were receiving lithium therapy was significantly higher than that of a different group of 38 subjects who were not receiving lithium therapy (p less than 0.005, t test). These observations may offer a biochemical mode of action for lithium in the treatment of bipolar affective disorder, since a deficiency of sodium pump activity has been shown to be associated with that disorder.
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