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  • Title: Functional difference between SERCA2a and SERCA2b Ca2+ pumps and their modulation by phospholamban.
    Author: Verboomen H, Wuytack F, De Smedt H, Himpens B, Casteels R.
    Journal: Biochem J; 1992 Sep 01; 286 ( Pt 2)(Pt 2):591-5. PubMed ID: 1326945.
    Abstract:
    COS 1 cells were transfected with full-length pig stomach sarcoplasmic/endoplasmic reticulum Ca2+ pump (SERCA)2a or SERCA2b cDNA. Ca2+ uptake by microsomes from transfected cells revealed that the Ca2+ affinity of the SERCA2b Ca2+ pump (K0.5 0.17 +/- 0.01 microM) was higher than that of the SERCA2a Ca2+ pump (K0.5 0.31 +/- 0.02 microM). Thapsigargin-sensitivity was found to be identical for the two isoforms. The Ca2+ affinity of both the SERCA2a and SERCA2b Ca2+ pumps was decreased by a factor of two when they were co-expressed with phospholamban.
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