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  • Title: [Evaluation of IgG-IgM antibodies against the Epstein-Barr virus nuclear antigen (EBNA-1) using ELISA].
    Author: Martínez Zapico R, Sobejano L, Llamazares I, Ladrón de Guevara C.
    Journal: Enferm Infecc Microbiol Clin; 1992 May; 10(5):281-3. PubMed ID: 1327168.
    Abstract:
    BACKGROUND: Evaluation of two commercial immunoenzymatic techniques (ELISA) for detection of anti-EBNA-1 IgG and IgM for diagnosis of Epstein-Barr virus mononucleosis. METHODS: Study of anti-EBNA-1 IgG and IgM in infectious mononucleosis and they have been compared with the detection of IgM antibodies to VCA by indirect immunofluorescence as the reference method. RESULTS: The sensitivity of the assay was 87.5%, the specificity was 89.4%, the positive predictive value was 91.4% and the negative predictive value was 85%. CONCLUSIONS: This technique can be useful in laboratories without the necessary equipment and experienced personnel for indirect immunofluorescence. It also can be used as a complementary determination to the anti-VCA IgM in the long lasting infectious mononucleosis, when this marker is negative.
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