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  • Title: [Effects of paradoxical sleep deprivation on the activity of opiate receptors isolated from synaptic membranes of the rat brain].
    Author: Taranova NP, Izykenova GA.
    Journal: Biull Eksp Biol Med; 1992 Jan; 113(1):11-3. PubMed ID: 1327275.
    Abstract:
    The specific binding of 3H-naloxone with opiate receptors isolated from brain synaptic membranes of control and paradoxical sleep deprived rats were studied. This extreme state was shown to reduce the naloxone-binding activity of synaptic membranes by 35% and isolated receptors by 25-28%. The values of Kd and Bmax were calculated for isolated opiate receptors at different stages of purification. Considerable decrease of 3H-naloxone binding sites density (2 times) in the isolated opiate receptors with simultaneous increase of their affinity (3-4,5 times) was found following 24 hours paradoxical sleep deprivation. These findings suggest development of fixed alterations in the structure and functions of integral receptor proteins under extreme influences.
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