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  • Title: The effect of chronic and acute administration of deuterium oxide (D2O) on vascular smooth muscle contraction in spontaneously hypertensive and Wistar-Kyoto rats.
    Author: McWilliam TM, Liepins A, Rankin AJ.
    Journal: Gen Pharmacol; 1992 Jul; 23(4):709-13. PubMed ID: 1327948.
    Abstract:
    1. Oral administration of 25% D2O for 12 days reduced blood pressure of spontaneously hypertensive rats (SHR) to the level of Wistar-Kyoto (WKY) controls. 2. However, the chronic D2O treatment appeared to have little effect on the phenylephrine and potassium chloride induced dose-response curves of SHR and WKY rats, producing a decreased maximal contraction of the potassium chloride dose-response curve of SHR only. 3. Further acute studies revealed that desensitization results from chronic exposure to D2O such that 60% D2O produces a significant depression of contraction only in aortic rings obtained from SHR and WKY which had not been chronically treated with 25% D2O.
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