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  • Title: [The effect of the deprivation of the paradoxical sleep stage on the temporal dynamics of swimming in rats with antidepressive and depressant exposures].
    Author: Baturin VA, Arushanian AE.
    Journal: Zh Vyssh Nerv Deiat Im I P Pavlova; 1992; 42(2):372-7. PubMed ID: 1329391.
    Abstract:
    After REM sleep deprivation the time-course of the forced swimming was reorganized. As shown, reduction of rhythmical index of depression, such effect has an antidepressive nature. In this model potentiation of specific activity of antidepressant imipramine and attenuation of depressive properties of clonidine were observed. These results suggest that shifts in sleep phase structure may be a source of restriction of circadian desynchronosis, upon which depression is based.
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