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  • Title: [Effects of Cu2+ on the neuromuscular junction transmission].
    Author: Qi YF, Che XP.
    Journal: Yao Xue Xue Bao; 1992; 27(2):81-5. PubMed ID: 1329436.
    Abstract:
    Experiments were carried out on the isolated rat phrenic nerve diaphragm preparations and chick biventer cervicis preparations. Cu2+ at cumulative concentrations inhibited muscle contractile response to indirect stimulation without affecting the conductivity of the nerve. The inhibiting action of Cu2+ on the muscle contractile response to indirect stimulation was stronger than that to direct stimulation. Cu2+ did not affect the Ach sensitivity of the chick biventer cervicis muscle. The effects of Cu2+ on neuromuscular transmission were antagonized by Ca2+ and L-cysteine. It is concluded that Cu2+ produces neuromuscular blockade by acting mainly on the presynaptic nerve terminals, binding with the -SH groups of the membrane and thus altering the transmembrane movement of Ca2+ and reducing the release of Ach from the nerve terminals.
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