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  • Title: Stimulation of host-defense mechanism with synthetic adjuvants and recombinant cytokines against viral infection in mice.
    Author: Azuma I, Ishihara C, Iida J, Yoo YC, Yoshimatsu K, Arikawa J.
    Journal: Adv Exp Med Biol; 1992; 319():253-63. PubMed ID: 1329443.
    Abstract:
    The efficacy of synthetic immunoadjuvants and recombinant cytokines for the potentiation of host-resistance against virus infection was investigated using mouse models infected with Sendai virus and herpes simplex type 1 virus (HSV). The synthetic MDP derivative, MDP-Lys(L18), and recombinant cytokines, IL-1 beta, IFN-gamma, G-CSF and GM-CSF were shown to be effective for the stimulation of nonspecific protection against Sendai virus infection in mice. Both MDP-Lys(L18) and GM-CSF were effective for the protection against HSV infection in cyclophosphamide (CY)-treated mice. B30-MDP was suggested to be useful as an immunoadjuvant for the potentiation of antigenicity of recombinant or component vaccines.
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