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  • Title: In vitro activities of penciclovir and acyclovir against herpes simplex virus types 1 and 2.
    Author: Weinberg A, Bate BJ, Masters HB, Schneider SA, Clark JC, Wren CG, Allaman JA, Levin MJ.
    Journal: Antimicrob Agents Chemother; 1992 Sep; 36(9):2037-8. PubMed ID: 1329640.
    Abstract:
    Penciclovir (PCV) and acyclovir are acyclic guanine analogs which inhibit herpes simplex virus (HSV) DNA polymerase. Their 50% infective doses were 0.5 to 0.8 microgram/ml for clinical isolates of HSV-1 and 1.3 to 2.2 micrograms/ml for HSV-2. Furthermore, HSV-infected cultures receiving 2-h pulses of PCV had 2- to 50-fold less HSV than acyclovir-treated cultures, consistent with the prolonged intracellular half-life of PCV triphosphate.
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