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  • Title: [The regulation of respiration under the conditions of the altered density of a gaseous environment during muscular work].
    Author: Segizbaeva MO, Isaeva GG.
    Journal: Fiziol Zh SSSR Im I M Sechenova; 1992 Mar; 78(3):14-25. PubMed ID: 1330744.
    Abstract:
    In 10 young healthy subjects, both at resting and in muscular work, the substitution of air by a helium-oxygen mixture reduced the central inspiratory drive, the work of breathing, and electrical activity of inspiratory muscles, whereas the inhalation of elegas-oxygen mixture led to obvious opposite effects: the effort for even the least maximal inspiratory flow increased in the same lung ventilation as when breathing air and in constant chemoreceptor stimulus; the central inspiratory activity increased nearly three-fold. The mechanism of the load compensation and of the respiratory system's load seems to be mediated mainly through the afferents from the respiratory muscles' proprioreceptors.
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