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  • Title: Sex hormone binding globulin: the carrier protein for d-norgestrel.
    Author: Victor A, Weiner E, Johansson ED.
    Journal: J Clin Endocrinol Metab; 1976 Jul; 43(1):244-7. PubMed ID: 133117.
    Abstract:
    The binding of different synthetic steroids, used in hormonal contraception, to Sex Hormone Binding Globulin (SHBG) was studied by measuring their ability to displace tritiated testosterone from SHBG in a competitive protein binding system. Only 19-nortestosterone derivates had any significant ability to displace testosterone from SHBG, d-norgestrel (d-Ng) being the strongest displacer. Increasing the SHBG levels in women with previous constant plasma d-Ng levels increased these levels two- to sixfold. It is concluded that SHBG is the main carrier protein for d-Ng. The strong testosterone displacing activity of d-Ng might also explain androgenic side effects observed with d-Ng containig oral contraceptives.
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