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  • Title: [Mechanism of vitamin B6 regulation of acetylcholine-induced currents in mollusk neurons: pre- and postsynaptic effects].
    Author: Diatlov VA, Diatlova EN.
    Journal: Neirofiziologiia; 1992; 24(4):411-22. PubMed ID: 1331822.
    Abstract:
    Vitamin B6 has been studied for the mechanism of its effect on acetylcholine-induced sodium-potassium and chloride currents in E16 neuron of isolated brain of the snail Helix pomatia. The results indicate that the effect of vitamin B6 on acetylcholine-induced currents in postsynaptic neuron E16 is mediated via changes in gamma-aminobutyric acid (GABA) release from a presynaptic neuron and subsequent GABA-induced and cAMP-dependent processes in E16 neuron. It is suggested that effects of vitamin and antivitamin B6 on axons of a presynaptic neuron or neurons may be connected with regulation of GABA synthesis from glutamate catalyzed by the pyridoxal-phosphate-containing enzyme.
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