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  • Title: Studies on non-precipitating antibody. I. The conversion of non-precipitating antibody to a precipitin-like material in vitro.
    Author: STERNBERGER LA, FEINBERG SM, CLARKE ME.
    Journal: J Exp Med; 1956 May 01; 103(5):523-44. PubMed ID: 13319576.
    Abstract:
    Brief exposure of serum to alkali in the cold seems to convert non-precipitating antibody to a precipitin-like material. This was disclosed by the following lines of evidence. 1. Immune sera, after addition of antigen and removal of the ensuing precipitates, yielded after alkali treatment more antibody-antigen complex than did sera to which no antigen was added. 2. When immune sera were depleted of precipitating antibody, treated by alkali, and antibody-antigen complex was allowed to precipitate, the resulting supernates formed additional prescipitates upon admixture of specific antigen. No precipitation occurred upon addition of non-specific protein to the treated supemates or the addition of specific antigen to depleted sera not treated by alkali. 3. Alkali-treated immune sera precipitated more antigen than untreated sera.
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