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Title: [The functional role of enhanced cellular excitability and synaptic efficiency in the neocortex during learning]. Author: Kozhedub RG. Journal: Zh Vyssh Nerv Deiat Im I P Pavlova; 1992; 42(4):664-71. PubMed ID: 1332284. Abstract: In experiments with noncurarized and unanaesthetized rabbits was recorded pyramidal tract response in the course of conditioning of direct stimulations of the two points of the cortical surface. The data obtained point to temporary specificity in manifestation of the membrane and synaptic plasticity, to participation of these mechanisms in the processes proceeding in both cortical representations of paired stimuli, and to predominantly undirected changes of a degree of their involvement in both cortical areas. At the early stage of conditioning were demonstrated all the characteristics of the dominant state developing at this stage, and at the late one those of differential conditioning. A conclusion is drown that the reinforcement through the membrane plasticity leads to initial dominant increase of cellular excitability. On the background of the latter by means of summation mechanism the conditions are created for excitation transmission from the sensory link of a new bond to its motor output. Underlined by the mechanisms of synaptic plasticity gradual reorganization of the excitatory and inhibitory connections to the output elements of conditioned response determines and consolidates specialized character of the elaborated reaction.[Abstract] [Full Text] [Related] [New Search]