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  • Title: [Homozygosity and atypical myeloproliferative syndrome (author's transl)].
    Author: Berger R, Brière J, Clauvel JP.
    Journal: Nouv Rev Fr Hematol; 1975; 15(6):667-76. PubMed ID: 133336.
    Abstract:
    An abnormal clone with four chromosomal rearrangements was found in the bone marrow of a patient with an atypical myeloproliferative syndrome and with an almost exclusive polymorphonuclear hyperplasia in blood: t (4;12), i(17 q),20q--. An heterozygosity for a normal variant of one chromosome No. 3 was observed in blood cell cultures. In bone marrow however both chromosomes No. 3 had the same Q-banding patterns. A mechanism of somatic segregation may explain this partial homozygosity.
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