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  • Title: Dihydroergotoxine modulation of the GABAA receptor-associated Cl- ionophore in mouse brain.
    Author: Tvrdeić A, Pericić D.
    Journal: Eur J Pharmacol; 1992 Oct 06; 221(1):139-43. PubMed ID: 1333969.
    Abstract:
    Dihydroergotoxine non-competitively displaced the binding of t-[3H]butylbicycloorthobenzoate ([3H]TBOB) to crude synaptosomal membranes from the mouse brain (cerebrum minus cortex), and gamma-aminobutyric acid (GABA) (10 microM) enhanced the displacement potency of dihydroergotoxine in a bicuculline-sensitive manner. The same ergot compound prolonged pentobarbital-induced sleeping in mice and diminished the convulsive potency of picrotoxin in the same animal species. The results are indicative of the positive coupling between GABA and dihydroergotoxine.
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