These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Isoprenaline reverses the slow force responses to a length change in isolated rabbit papillary muscle.
    Author: Kentish JC, Davey R, Largen P.
    Journal: Pflugers Arch; 1992 Aug; 421(5):519-21. PubMed ID: 1334258.
    Abstract:
    An alteration in the length of isolated cardiac muscle produces an immediate change in twitch force, then a slow further change in the same direction. We have found that the slow changes in force in rabbit papillary muscles are blocked or reversed by the beta-agonist, isoprenaline (1 microM). The abolition of the slow responses by isoprenaline was not due to saturation of the myofibrils with Ca2+, as the blockade continued if the extracellular [Ca2+] was reduced in the presence of isoprenaline so that twitch force was < 50% maximal. Ryanodine (1 microM) did not block the slow responses, suggesting that the sarcoplasmic reticulum does not mediate the responses. These results suggest that changes of intracellular [cAMP] may mediate, or at least modulate, the slow force responses to a length change in cardiac muscle.
    [Abstract] [Full Text] [Related] [New Search]