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  • Title: Kallikrein-kinin,enkephalin, renin-aldosterone and catecholamine systems in the vanadate (as vanadyl)-induced arterial hypertension.
    Author: Carmignani M, Preziosi P, Del Carmine R, Porcelli G, Volpe AR.
    Journal: Agents Actions Suppl; 1992; 38 ( Pt 3)():243-7. PubMed ID: 1334353.
    Abstract:
    Exposure to vanadate was found to induce arterial hypertension through effects on renin-angiotensin-aldosterone, renal peptidergic, and central and peripheral catecholaminergic systems. Vanadate increased, mainly in vascular myocells, both receptor-operated Ca2+ channel- and cyclic-AMP-dependent availability of Ca2+ for contractile processes. Vanadate was selectively accumulated by tissues in the +4 oxidation state (vanadyl).
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