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  • Title: Purification and characterization of phosphatidylinositol 4-phosphate 5-kinases.
    Author: Divecha N, Brooksbank CE, Irvine RF.
    Journal: Biochem J; 1992 Dec 01; 288 ( Pt 2)(Pt 2):637-42. PubMed ID: 1334412.
    Abstract:
    We detail the purification and characterization of three distinct isoforms of PtdIns4P 5-kinase present in bovine brain. One of these, PtdIns4P 5-kinase C, was purified to apparent homogeneity, and SDS/PAGE analysis demonstrated a single polypeptide and molecular mass 53 KDa. These three isoforms were shown to differ in their kinetic properties, and immunological characterization with an antibody raised to PtdIns4P 5-kinase C demonstrated that this isoform was unrelated to the other two. Furthermore, PtdIns4P 5-kinase C was shown to be the bovine brain homologue of the Type II PtdIns4P 5-kinase previously purified from human erythrocytes [Bazenet, Ruano, Brockman & Anderson (1990) J. Biol. Chem. 265, 18012-18022].
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