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  • Title: Direct cell mediated lympholysis by peripheral blood lymphocytes from renal allograft recipients.
    Author: Grunnet N, Kristensen T.
    Journal: Scand J Urol Nephrol; ; (29 Suppl):41-4. PubMed ID: 133456.
    Abstract:
    Investigations of 22 kidney allograft recipients by the Direct CML-test revealed coincidence between acute allograft rejection and a positive test. 15 patients exhibited acute rejection, 3 chronic, and 4 no rejection episodes. 4 patients with acute rejection were not detected as positive in Direct CML, while 3 patients were positive without acute rejection, one having a chronic rejection. The exact role of HL-A antigens for the specificity of a positive Direct CML could not be evaluated from this material. It is concluded that the Direct CML-test may be helpful for the diagnosis of acute rejection, but that it has only limited power as the only test of recipients' response to foreign tissue.
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