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  • Title: Malignant placental site trophoblastic tumor associated with placental abruption, fetal distress, and elevated CA-125.
    Author: Hopkins MP, Drescher CW, McQuillan A, Keyser J, Schmidt R.
    Journal: Gynecol Oncol; 1992 Nov; 47(2):267-71. PubMed ID: 1334939.
    Abstract:
    The second pregnancy of 27-year-old woman, gravida 2, para 2 was complicated by a low alpha-fetoprotein and symptoms of chronic placental abruption. She delivered by cesarean section at 35 weeks for fetal distress at which time a biopsy of the uterus revealed a placental site trophoblastic tumor (PSTT). She rapidly developed intraabdominal spread of the neoplasm which did not respond to chemotherapy and she died 10 weeks later. Her CA-125 was elevated to 5360 mu/ml and this decreased after hysterectomy. This patient is reported to highlight a very malignant course of PSTT that was associated with a live-born male infant.
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