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  • Title: The clinical significance of the thyrotropin-releasing hormone test in alcoholic men.
    Author: Sellman JD, Joyce PR.
    Journal: Aust N Z J Psychiatry; 1992 Dec; 26(4):577-85. PubMed ID: 1335721.
    Abstract:
    Sixty-six alcoholic men who had been abstinent from alcohol for at least four weeks were assessed clinically and then investigated in terms of Thyroid-Stimulating Hormone (TSH) and prolactin responses to a Thyrotropin-Releasing Hormone (TRH) challenge. Consistent with other studies, a third of the subjects had a blunted TSH response to TRH. This blunted response was not associated with a family history of alcoholism, or current depressive symptoms, past history of depression or family history of depression. However, subjects with a blunted TSH response were more likely to have had an earlier onset of alcoholism and to have had shorter alcoholic remissions in the past.
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