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  • Title: [The influence of epiphysectomy and melatonin on the antidepressive effect in disordered function of the beta-adrenergic mechanisms in rats].
    Author: Arushanian EB, Beĭer EV.
    Journal: Zh Vyssh Nerv Deiat Im I P Pavlova; 1992; 42(5):993-7. PubMed ID: 1336286.
    Abstract:
    After chronic administration of beta-adrenoblocker propranolol (1 mg/kg, 14 days) reorganization of time course of forced swimming with decrease of rhythmical index of depression was observed. Pinealectomy slightly attenuated, and melatonin (1 mg/kg) potentiated this effect. As proposed, antidepressive properties of beta-adrenoblockade primarily are not connected with pharmacological denervation of the pineal gland.
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