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  • Title: [Inhibitory effect of IPD-1151T (suplatast tosilate) on mast cell induction from normal mouse spleen cells].
    Author: Kouno S, Adachi M, Asano K, Okamoto K, Takahashi T.
    Journal: Arerugi; 1992 Oct; 41(10):1488-91. PubMed ID: 1336362.
    Abstract:
    The effects of IPD-1151T (suplatast tosilate), a novel anti-allergic drug, on murine mast cell induction were examined by the in vitro cell culture technique. Spleen cells from BALB/c mice suspended in RPMI-1640 medium containing interleukin 3 were cultured in the presence or absence of IPD-1151T. Half the volume of the medium was changed every 4 days. Mast cell numbers increased as the culture time went on and reached a peak on the 16th day, when spleen cells were cultured without IPD-1151T. However, induction of mast cells from spleen cell cultures was inhibited by IPD-1151T in a dose dependent fashion. These results strongly suggest that IPD-1151T is a very useful agent for therapy in allergic diseases.
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