These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Molecular biology of regulation of renal function--structure, function and distribution of the receptor--insulin, glucagon].
    Author: Nagasaka Y, Kaneko T.
    Journal: Nihon Rinsho; 1992 Dec; 50(12):2921-4. PubMed ID: 1337116.
    Abstract:
    Insulin and glucagon are known to regulate both metabolic and transport functions in the nephron, directly. Insulin receptor is a heterotetrameric glycoprotein, consisting of two alpha-subunits and two beta-subunits linked by disulfide bonds. Binding of insulin to its receptor in the proximal basolateral membranes results in phosphorylation of beta-subunit which is considered to be necessary to subsequent activation of receptor tyrosine kinase. Insulin receptors are also present in the luminal membranes of the proximal tubules. Proximal tubules are major sites of insulin and glucagon degradation. Insulin and glucagon regulate mineral transport mainly at the thick ascending limb. Insulin and glucagon regulate gluconeogenesis in the kidney.
    [Abstract] [Full Text] [Related] [New Search]